A selective and irreversible inhibitor of NF-κB activation that blocks TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation; inhibits the TNFα-induced surface expression of adhesion molecules ICAM-1

BAY 11-7082 – 5 mg

Brand:
Cayman
CAS:
19542-67-7
Storage:
-20
UN-No:
Non-Hazardous - /

The transcription factor NF-κB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules.{13643} In the cytoplasm, inactive NF-κB complexes are bound to an inhibitor IκB.{12959} However in response to certain stimuli, IκB is phosphorylated, ubiquitinated, and degraded, enabling the translocation of NF-κB to the nucleus.{13642} BAY 11-7082 selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation.{16037} This compound inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 µM.{16037}  

 

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SKU: 10010266 - 5 mg Category:

Description

A selective and irreversible inhibitor of NF-κB activation that blocks TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation; inhibits the TNFα-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50 = 5-10 µM)

Formal name: 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile

Synonyms: 

Molecular weight: 207.3

CAS: 19542-67-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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