An activator of AMPK; increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 μM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells; inhibits insulin-stimulated glucose uptake to 62% of control cells and reduces GLUT4 translocation by 2.5-fold in 3T3-L1 adipocytes at 0.5 mM; prevents increases in protein levels of iNOS

AICAR – 100 mg

Brand:
Cayman
CAS:
2627-69-2
Storage:
-20
UN-No:
Non-Hazardous - /

AICAR is an activator of AMP-activated protein kinase (AMPK).{15379} It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 μM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and reduces GLUT4 translocation by 2.5-fold in 3T3-L1 adipocytes.{15378} In astrocyte-enriched glial cells, AICAR (1 mM) prevents increases in protein levels of inducible nitric oxide synthase (iNOS), COX-2, and manganese superoxide dismutase (MnSOD) induced by LPS and amyloid-β (Aβ) (25-35) and expression of TNF-α, IL-1β, and IL-6 induced by LPS and Aβ42.{15380} AICAR inhibits autophagy in rat hepatocytes (IC50 = 0.3 mM) and induces apoptosis in rat β cells in a concentration-dependent manner.{47609,47610}  

 

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SKU: 10010241 - 100 mg Category:

Description

An activator of AMPK; increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 μM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells; inhibits insulin-stimulated glucose uptake to 62% of control cells and reduces GLUT4 translocation by 2.5-fold in 3T3-L1 adipocytes at 0.5 mM; prevents increases in protein levels of iNOS, COX-2, and MnSOD induced by LPS and amyloid-β (Aβ) (25-35) and expression of TNF-α, IL-1β, and IL-6 induced by LPS and Aβ42 in astrocyte-enriched glial cells at 1 mM; inhibits autophagy in rat hepatocytes (IC50 = 0.3 mM) and induces apoptosis in rat β cells

Formal name: 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide

Synonyms:  Acadesine|AICA-Riboside|NSC 105823

Molecular weight: 258.2

CAS: 2627-69-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Nutrient Sensing||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Fatty Acids|Synthesis||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience

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