A cell-permeable quinone epoxide that selectively inhibits BTK catalytic activity (BTK; IC50s = 10 and 3 µM for basal and activation levels

Terreic Acid – 1 mg

Brand:
Cayman
CAS:
121-40-4
Storage:
-20
UN-No:
Non-Hazardous - /

Terreic acid (TA) is a cell-permeable quinone epoxide that selectively inhibits Bruton’s tyrosine kinase (BTK) catalytic activity (IC50s = 10 and 3 µM for basal and activation levels, respectively).{31003,38003,38004} TA binds to the BTK pleckstrin homology domain (BTK-PH) and blocks the interaction between BTK-PH and PKC (IC50 = 100 µM in human mast cell lysates) without affecting the activity of PKC.{38003,38004} TA has minimal effect on Lyn, Syk, PKA, casein kinase I, ERK1, ERK2, and p38 kinase activities.{38004,38005}  

 

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SKU: 10010235 - 1 mg Category:

Description

A cell-permeable quinone epoxide that selectively inhibits BTK catalytic activity (BTK; IC50s = 10 and 3 µM for basal and activation levels, respectively); binds to BTK-PH and blocks the interaction between BTK-PH and PKC (IC50 = 100 µM in human mast cell lysates) without affecting PKC activity; minimal effect on Lyn, Syk, PKA, casein kinase I, ERK1, ERK2, and p38 kinase activities,

Formal name: (1R,6S)-3-hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione

Synonyms:  (-)-Terreic Acid|TA

Molecular weight: 154.1

CAS: 121-40-4

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Tec Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area

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