An ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM

(R)-Equol – 5 mg

Brand:
Cayman
CAS:
221054-79-1
Storage:
-20
UN-No:
Non-Hazardous - /

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora.{16628,16720} It is a chiral molecule that exists in two enantiomeric forms.{16720} In contrast to the estrogen receptor (ER) selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively.{16628} The (R)-enantiomer demonstrates higher ER agonist activity at ERα compared to ERβ (EC50 = 66 and 330 nM, respectively).{16720}  

 

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SKU: 10010172 - 5 mg Category:

Description

An ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively; demonstrates higher ER agonist activity at ERα compared to ERβ (EC50 = 66 and 330 nM, respectively)

Formal name: 3,4-dihydro-3R-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

Synonyms:  (+)-Equol|Isoequol

Molecular weight: 242.3

CAS: 221054-79-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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