A LPA analog containing stearic acid at the sn-1 position; has potent platelet aggregating activity with an EC50 value of 9 nM

1-Octadecyl Lysophosphatidic Acid – 1 mg

Brand:
Cayman
CAS:
52977-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

1-Octadecyl lysophosphatidic acid (1-octadecyl LPA) is a LPA analog containing stearic acid at the sn-1 position. LPA binds to one of five different G protein linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.{13001,2656} Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has a platelet aggregating EC50 value of 9 nM versus 1-octadecanoyl LPA which has an EC50 value of 177 nM.{15053}  

 

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SKU: 10010164 - 1 mg Category:

Description

A LPA analog containing stearic acid at the sn-1 position; has potent platelet aggregating activity with an EC50 value of 9 nM

Formal name: 3-(octadecyloxy)-1-(dihydrogen phosphate)-1,2-propanediol

Synonyms:  1-Octadecyl LPA

Molecular weight: 424.6

CAS: 52977-29-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Lipid Biochemistry|Glycerophospholipids

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