An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression; dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 µM) without affecting COX-2 expression

CAY10526 – 10 mg

Brand:
Cayman
CAS:
938069-71-7
Storage:
-20
UN-No:
Non-Hazardous - /

Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1).{11266,12923,11537} CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 µM without any effect on COX-2 expression.{14793}  

 

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SKU: 10010088 - 10 mg Category:

Description

An inhibitor of PGE2 production through the selective modulation of mPGES-1 expression; dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells (IC50 = 1.8 µM) without affecting COX-2 expression

Formal name: 4-(benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one

Synonyms: 

Molecular weight: 311.1

CAS: 938069-71-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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