A selective

CAY10561 – 10 mg

Brand:
Cayman
CAS:
933786-58-4
Storage:
-20
UN-No:
Non-Hazardous - /

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary.{15420} CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM).{14786} This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM).{14786} CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.{14786}  

 

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SKU: 10010043 - 10 mg Category:

Description

A selective, potent inhibitor of ERK2 (Ki = 2 nM); inhibits proliferation of COLO 205 cells (IC50 = 0.54 µM)

Formal name: N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide

Synonyms:  Pyrazolylpyrrole ERK Inhibitor

Molecular weight: 459.3

CAS: 933786-58-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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