A side-chain substituted oxysterol that has important roles in cholesterol homeostasis; potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM

24(S)-hydroxy Cholesterol – 1 mg

Brand:
Cayman
CAS:
474-73-7
Storage:
-20
UN-No:
Non-Hazardous - /

24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that has important roles in cholesterol homeostasis. It is generated by the action of CYP46 on cholesterol in the brain and diffuses across the blood-brain barrier to the systemic circulation where it can modulate cell signaling, be used for further sterol biosynthesis, or be metabolized in the liver.{15406} 24(S)-hydroxy cholesterol potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes.{15406,25539,15410} In the brain, this oxysterol controls cholesterol processing to facilitate neurological repair during Alzheimer’s disease and other neuropathological conditions.{15406}  

 

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SKU: 10009931 - 1 mg Category:

Description

A side-chain substituted oxysterol that has important roles in cholesterol homeostasis; potently activates LXRα and LXRβ nuclear receptors (EC50 = 4 and 3 μM, respectively), causing upregulation of cholesterol-lowering genes

Formal name: cholest-5-ene-3β,24S-diol

Synonyms:  Cerebrosterol

Molecular weight: 402.7

CAS: 474-73-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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