GW 590735 is a potent and selective agonist of peroxisome proliferator-activated receptor (PPAR)α with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPAR.delta..{14733}

GW 590735 – 5 mg

Brand:
Cayman
CAS:
622402-22-6
Storage:
-20
UN-No:
Non-Hazardous - /

The peroxisome proliferator-activated receptors (PPARs) α, γ, and δ are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARα results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels of ApoCIII and in upregulation of ApoA1, the principal lipoprotein component of HDL.{14733} GW 590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ.{14733}  

 

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SKU: 10009880 - 5 mg Category:

Description

GW 590735 is a potent and selective agonist of peroxisome proliferator-activated receptor (PPAR)α with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPAR.delta..{14733}

Formal name: 2-methyl-2-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)methyl)phenoxy)propanoic acid

Synonyms: 

Molecular weight: 478.5

CAS: 622402-22-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs

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