A selective CB2 receptor inverse agonist (Kds = 25 and 2

JTE-907 – 5 mg

Brand:
Cayman
CAS:
282089-49-0
Storage:
-20
UN-No:
Non-Hazardous - /

JTE-907 is a selective peripheral cannabinoid (CB2) receptor agonist with Kd values of 25 and 2,370, 1.55 and 1,060, and 0.38 and 1,050 nM for human, mouse, and rat CB2 and CB1 receptors, respectively.{14732} It increases forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB2 in a dose-dependent manner. In vivo, JTE-907 inhibits carrageenin-induced edema in mouse paws with an ED50 value of 0.05 mg/kg. JTE-907 also inhibits spontaneous scratching in a mouse model of chronic dermatitis at doses of 1 and 10 mg/kg.{14731}  

 

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SKU: 10009857 - 5 mg Category:

Description

A selective CB2 receptor inverse agonist (Kds = 25 and 2,370, 1.55 and 1,060, and 0.38 and 1,050 nM for human, mouse, and rat CB2 and CB1 receptors, respectively); increases forskolin-stimulated cAMP production in CHO cells expressing human and mouse CB2 in a dose-dependent manner; inhibits carrageenin-induced edema in mouse paws (ED50 = 0.05 mg/kg); inhibits spontaneous scratching in a mouse model of chronic dermatitis

Formal name: N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide

Synonyms: 

Molecular weight: 438.5

CAS: 282089-49-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation

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