A potent

MK-0524 – 5 mg

Brand:
Cayman
CAS:
571170-77-9
Storage:
-20
UN-No:
Non-Hazardous - /

MK-0524 is a potent, selective prostaglandin D2 (PGD2)receptor DP1 antagonist with Ki values of 0.57 nM and 0.75 µM for the DP1 and DP2 receptors, respectively.{14713} It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively.{14713} In a sheep model of allergic rhinitis, 0.1 mg/kg MK-0524 completely blocked PGD2-induced nasal congestion.{14713} At a dose of 4 mg/kg, MK-0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a mouse model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.{15245} In an in vitro model of amyotrophic lateral sclerosis, MK-0524 has been shown to partially protect cultured motor neurons from PGD2-induced toxicity.{33495,33496}  

 

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SKU: 10009835 - 5 mg Category:

Description

A potent, selective DP1 receptor antagonist that binds DP1 and DP2 receptors with Ki values of 0.57 nM and 0.75 µM, respectively

Formal name: (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid

Synonyms:  Laropiprant

Molecular weight: 435.9

CAS: 571170-77-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Immunology & Inflammation|Allergy||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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