A CB1 receptor inverse agonist (Ki = 0.13 nM); selective for CB1 over CB2 receptors (Ki = 170 nM)

Taranabant – 5 mg

Brand:
Cayman
CAS:
701977-09-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Taranabant is a cannabinoid (CB) receptor 1 inverse agonist (Ki = 0.13 nM).{57169} It is selective for CB1 over CB2 receptors (Ki = 170 nM), as well as a panel of 170 receptors, enzymes, ion channels, and transporters at 1 µM. Taranabant increases forskolin-induced cAMP production in CHO cell membranes expressing human CB1 (EC50 = 2 nM). In vivo, taranabant (3 mg/kg) reverses hypothermia induced by the CB receptor agonist CP 55,940 in rats. Taranabant (1 and 3 mg/kg) reduces two-hour and overnight food intake, as well as overnight weight gain in wild-type, but not CB1 receptor-deficient, mice.  

 

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SKU: 10009795 - 5 mg Category:

Description

A CB1 receptor inverse agonist (Ki = 0.13 nM); selective for CB1 over CB2 receptors (Ki = 170 nM), as well as a panel of 170 receptors, enzymes, ion channels, and transporters at 1 µM; increases forskolin-induced cAMP production in CHO cell membranes expressing human CB1 (EC50 = 2 nM); reverses hypothermia induced by the CB receptor agonist CP 55,940 in rats at 3 mg/kg; reduces two-hour and overnight food intake, as well as overnight weight gain in wild-type, but not CB1 receptor-deficient, mice at 1 and 3 mg/kg

Formal name: N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-propanamide

Synonyms:  MK-0364

Molecular weight: 516

CAS: 701977-09-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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