Description
A multi-kinase inhibitor; inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively); inhibits VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively); selective for these kinases over 12 other kinases (IC50s = >10 µM for all); inhibits proliferation of PLC/PRF/5 and HepG2 cells (IC50s = 6.3 and 4.5 µM, respectively); inhibits tumor growth in a PLC/PRF/5 mouse xenograft model at 30 mg/kg; induces ferroptotic cell death in HT-1080 fibrosarcoma cells at 10 µM; inhibits HCV replication in Huh7.5 cells (IC50 = 7.2 µM)
Formal name: 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Synonyms: BAY 43-9006
Molecular weight: 464.8
CAS: 284461-73-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
