A metabolically stable methyl sulfonamide analog of 14(15)-EET; equipotent to 14(15)-EET in vascular agonist activity

(±)14(15)-EET-SI – 100 µg

Brand:
Cayman
CAS:
218461-97-3
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Arachidonic acid is metabolized in the vascular endothelium to epoxytrienoic acids (EETs or EpETrEs) by cytochrome P450 enzymes. The EETs are released in response to acetylcholine, bradykinin, arachidonic acid, or cyclic stretch.{14714} (±)14(15)-EET-SI is the methyl sulfonamide analog of 14(15)-EET. This substitution results in a metabolically more stable compound because it is not sensitive to β-oxidation or membrane esterification. (±)14(15)-EET-SI is equipotent to 14(15)-EET in vascular agonist activity as measured by relaxation of precontracted bovine coronary arteries.{14714} In addition, 14(15)-EET and the methyl sulfonamide analog both stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.{14383}  

 

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SKU: 10009286 - 100 µg Category:

Description

A metabolically stable methyl sulfonamide analog of 14(15)-EET; equipotent to 14(15)-EET in vascular agonist activity

Formal name: N-(methylsulfonyl)-13-(3-pentyloxiranyl)-5Z,8Z,11Z-tridecatrienamide

Synonyms:  ​14(15)-EET-SI|14(15)-EET-sulfonimide|14,15-EpETrE-SI

Molecular weight: 397.6

CAS: 218461-97-3

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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