An SPHK1 inhibitor (IC50 = 0.5 µM for non-ATP-competitive inhibition of human recombinant SPHK1); selective for SPHK1 over ERK2

Sphingosine Kinase Inhibitor 2 – 10 mg

Brand:
Cayman
CAS:
312636-16-1
Storage:
-20
UN-No:
Non-Hazardous - /

Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} Sphingosine kinase inhibitor 2 is an inhibitor of sphingosine kinase 1 (SPHK1) with an IC50 value of 0.5 µM for non-ATP-competitive inhibition of human recombinant SPHK1.{11597} It is selective for SPHK1 over ERK2, PI3K, and PKCα at concentrations up to 60 µM. Sphingosine kinase inhibitor 2 inhibits proliferation of several cancer cell lines, including T-24, MCF-7, NCI/ADR, and MCF-7/VP (IC50s = 0.9-4.6 µM).  

 

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SKU: 10009222 - 10 mg Category:

Description

An SPHK1 inhibitor (IC50 = 0.5 µM for non-ATP-competitive inhibition of human recombinant SPHK1); selective for SPHK1 over ERK2, PI3K, and PKCα at 50s = 0.9-4.6 µM),

Formal name: 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol

Synonyms:  SKI II|SPHK I2

Molecular weight: 302.8

CAS: 312636-16-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling||Research Area|Lipid Biochemistry|Sphingolipids

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