A potent inhibitor of PI3Kγ

CAY10505 – 25 mg

Brand:
Cayman
CAS:
328960-84-5
Storage:
-20
UN-No:
Non-Hazardous - /

Phosphoinositide 3-kinase γ (PI3Kγ), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively).{14230} Tested against a panel of 80 other kinases, CAY10505 significantly inhibits only the unrelated casein kinase 2 (CK2, IC50 = 20 nM). It also inhibits the phosphorylation of the PI3K substrate PKB/Akt in mouse macrophages (IC50 = 228 nM).{14230} Oral administration of CAY10505 reduces neutrophil recruitment in mice to an extent that is comparable to that observed in PI3Kγ-deficient mice.{14230}  

 

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SKU: 10009078 - 25 mg Category:

Description

A potent inhibitor of PI3Kγ, selectively inhibiting the γ isoform (IC50 = 30 nM) better than the α, β, and δ isoforms (IC50 = 0.94, 20, and 20 μM, respectively); inhibits phosphorylation of PKB/Akt in mouse macrophages (IC50 = 228 nM)

Formal name: 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

Synonyms: 

Molecular weight: 289.3

CAS: 328960-84-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Immunology & Inflammation|Innate Immunity

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