A stabilized ethyl ester form of this ω-3 C20:5 PUFA; dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels

Eicosapentaenoic Acid ethyl ester – 500 mg

Brand:
Cayman
CAS:
86227-47-6
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).{16509} EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes,{16250} suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels,{16514,16499} indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.{16497} Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.{16498}  

 

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SKU: 10008884 - 500 mg Category:

Description

A stabilized ethyl ester form of this ω-3 C20:5 PUFA; dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels, down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels; blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression in rats fed a high-fat diet

Formal name: 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid, ethyl ester

Synonyms:  EPA ethyl ester

Molecular weight: 330.5

CAS: 86227-47-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Fatty Acids

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