A selective COX-2 inhibitor (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2

Celecoxib – 100 mg

Brand:
Cayman
CAS:
169590-42-5
Storage:
-20
UN-No:
Non-Hazardous - /

Celecoxib is a selective inhibitor of COX-2 (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively).{11633,8926} In vivo, celecoxib (0.3 ml of a 0.4% solution) administered intra-articularly reduces production of IL-1β, TNF-α, and MMP-3 as well as articular cartilage damage in a rabbit model of osteoarthritis.{41721} It reduces blood glucose and improves renal function and memory deficits via downregulation of COX-2 expression and increased BDNF -TrkB signaling in rats with diabetes induced by streptozotocin (Item No. 13104).{41722} Celecoxib also displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition.{12660,11712,13638} Formulations containing celecoxib have been used in the treatment of inflammation while circumventing the gastrointestinal toxicity associated with traditional non-steroidal anti-inflammatory drugs, however, the use of celecoxib has been tempered due to its ability to induce adverse cardiovascular events.{14766}  

 

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SKU: 10008672 - 100 mg Category:

Description

A selective COX-2 inhibitor (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively); reduces production of IL-1β, TNF-α, and MMP-3 as well as articular cartilage damage in a rabbit model of osteoarthritis at 3 ml of a 0.4% solution; reduces blood glucose and improves renal function and memory deficits in rats with streptozotocin-induced diabetes; displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition

Formal name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Synonyms:  SC-58635|YM-177

Molecular weight: 381.4

CAS: 169590-42-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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