CAY10502 is a potent inhibitor of cPLA2α with an IC50 value of 4.3 nM for the purified enzyme from human platelets.{14126} It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM

CAY10502 – 1 mg

Brand:
Cayman
CAS:
888320-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway.{14663} CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets.{14126} It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.{14126}  

 

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SKU: 10008657 - 1 mg Category:

Description

CAY10502 is a potent inhibitor of cPLA2α with an IC50 value of 4.3 nM for the purified enzyme from human platelets.{14126} It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively.{14126}

Formal name: 1-[3-[4-(decyloxy)phenoxy]-2-oxopropyl]-1H-indole-3,5-dicarboxylic acid, 3-methyl ester

Synonyms: 

Molecular weight: 523.6

CAS: 888320-29-4

Purity: ≥98% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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