A potent agonist at four of the sphingosine-1-phosphate (S1P) receptors with IC50 values of 0.2-6 nM

FTY720 Phosphate – 1 mg

Brand:
Cayman
CAS:
402615-91-2
Storage:
-20
UN-No:
Non-Hazardous - /

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} In vivo, FTY720 is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester.{11284,14769} FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.{11284,14769,14768}  

 

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SKU: 10008639 - 1 mg Category:

Description

A potent agonist at four of the sphingosine-1-phosphate (S1P) receptors with IC50 values of 0.2-6 nM

Formal name: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, 1-(dihydrogen phosphate)

Synonyms:  FTY720P

Molecular weight: 387.5

CAS: 402615-91-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Sphingolipids

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