A fluorescent substrate for calpain and papain (excitation max: 360 nm; emission max: 460 nm) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome

Suc-Leu-Tyr-AMC – 25 mg

Brand:
Cayman
CAS:
94367-20-1
Storage:
-20
UN-No:
Non-Hazardous - /

The calpains are a family of calcium-dependent cysteine proteases, with calpain I (µ-calpain) requiring micromolar calcium and calpain II (m-calpain) requiring millimolar calcium. Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; emission max: 460 nm).{29239,29240,29241} Suc-Leu-Tyr-AMC can also be cleaved by the Ti protease from E. coli.{13747}  

 

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SKU: 10008120 - 25 mg Category:

Description

A fluorescent substrate for calpain and papain (excitation max: 360 nm; emission max: 460 nm) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome

Formal name: N-(3-carboxy-1-oxopropyl)-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-tyrosinamide

Synonyms:  Suc-LY-AMC

Molecular weight: 551.6

CAS: 94367-20-1

Purity: ≥98%

Formulation: A crystalline solid

Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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