An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells

Perifosine – 10 mg

Brand:
Cayman
CAS:
157716-52-4
Storage:
-20
UN-No:
Non-Hazardous - /

Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines.{14118} Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5 µM at 24 h) and is associated with rapidly decreased Akt activation.{13739} In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.{14119}  

 

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SKU: 10008112 - 10 mg Category:

Description

An alkylphospholipid that induces apoptotic cell death in a time- and dose-dependent manner in a variety of tumor cell lines but not in normal vascular endothelial cells; causes inhibition of PC-3 prostate carcinoma cell growth (GI50 = 5 µM at 24h) associated with rapidly decreased Akt activation; induces p21WAF1 expression in squamous carcinoma cells, leading to loss in cyclin-dependent kinase activity and cell cycle arrest

Formal name: 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-piperidinium, inner salt

Synonyms: 

Molecular weight: 461.7

CAS: 157716-52-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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