An active metabolite of E-64d; inhibits cathepsin B

E-64c – 25 mg

Brand:
Cayman
CAS:
76684-89-4
Storage:
-20
UN-No:
Non-Hazardous - /

E-64c is an active metabolite of the protease inhibitor E-64d (Item No. 13533).{14249,58182,54647,54648} E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase.{17474,54649} It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml.{54647} E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.{54648}  

 

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SKU: 10007964 - 25 mg Category:

Description

An active metabolite of E-64d; inhibits cathepsin B, cathepsin H, and papain; reduces the autocatalytic activity of the FMDV leader protease from 0.1-1 mg/ml; reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein

Formal name: (2S,3S)-3[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-oxiranecarboxylic acid

Synonyms:  Loxistatin Acid|NSC 694279

Molecular weight: 314.4

CAS: 76684-89-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Immunology & Inflammation|Pulmonary Diseases|SARS||Research Area|Infectious Disease|Viral Diseases|Coronaviruses

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