A fungal metabolite with diverse biological activities; inhibits cathepsins B

E-64 – 5 mg

Brand:
Cayman
CAS:
66701-25-5
Storage:
-20
UN-No:
Non-Hazardous - /

E-64 is a fungal metabolite originally isolated from Aspergillus japonicus that has diverse biological activities.{52880,17474,54647,52881,52882} It inhibits a variety of cysteine proteases, including cathepsins B, H, and L, as well as papain, ficin, and bromelain, but not the serine proteases plasmin, trypsin, and tissue kallikrein or the aspartic protease pepsin.{17474,52880} E-64 (0.1-2 mg/ml) reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease.{54647} It is active against the FCR3 P. falciparum strain with an IC50 value of 836 nM.{52881} E-64 (5-25 µM) reduces bone resorption in embryonic mouse bone explants.{52882}  

 

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SKU: 10007963 - 5 mg Category:

Description

A fungal metabolite with diverse biological activities; inhibits cathepsins B, H, and L, as well as papain, ficin, and bromelain; reduces the autocatalytic activity of the FMDV leader protease from 0.1-2 mg/ml; active against the FCR3 P. falciparum strain (IC50 = 836 nM); reduces bone resorption in embryonic mouse bone explants from 5-25 µM

Formal name: (2S,3S)-3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid

Synonyms: 

Molecular weight: 357.4

CAS: 66701-25-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Viral Diseases

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