A thioester substrate analog of 2-AG that can be utilized for the measurement of MAGL activity; hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB resulting in a yellow product with an absorbance maximum at 412 nm

Arachidonoyl-1-thio-Glycerol – 5 mg

Brand:
Cayman
CAS:
1309664-54-7
Storage:
-80
UN-No:
De Minimis - 1648 / 3

2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor.{7182,7183} It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain.{7183,6819} Monoacylglycerol lipase (MAGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions.{11364} Arachidonoyl-1-thio-glycerol is a thioester substrate analog of 2-arachidonoyl glycerol that can be utilized for the measurement of MAGL activity.{13593} Hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB (Ellman’s reagent) resulting a yellow product with an absorbance maximum at 412 nm.  

 

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SKU: 10007904 - 5 mg Category:

Description

A thioester substrate analog of 2-AG that can be utilized for the measurement of MAGL activity; hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB resulting in a yellow product with an absorbance maximum at 412 nm

Formal name: 5Z,8Z,11Z,14Z-eicosatetraenyl,1-thio glycerol

Synonyms:  1-S-Arachidonoyl-1-mercapto-2,3-propanediol

Molecular weight: 394.6

CAS: 1309664-54-7

Purity: ≥95%

Formulation: A solution in acetonitrile

Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Lipids|Fatty Acid Conjugates||Product Type|Biochemicals|Lipids|Glycerolipids||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerolipids|Lipases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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