A dual agonist of PPARα and PPARγ (EC50s = 0.32 and 0.11 μM

Muraglitazar – 1 mg

Brand:
Cayman
CAS:
331741-94-7
Storage:
-20
UN-No:
Non-Hazardous - /

Muraglitazar is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ (EC50s = 0.32 and 0.11 μM, respectively).{13427} It is selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, estrogen receptor α (ERα), ERβ, androgen receptor (AR), and progesterone receptor (PR). Muraglitazar (50 μM) reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes.{42456} It reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice when administered at a dose of 10 mg/kg per day.{13427} Muraglitazar (10 mg/kg per day) reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice.{31312} Muraglitazar also inhibits LPS-induced increases in nitric oxide (NO) production and IL-6, TNF-α, and inducible nitric oxide synthase (iNOS) protein levels in J774 murine macrophages in a concentration-dependent manner.{42457} It inhibits carrageenan-induced paw edema in mice when administered at doses ranging from 12.5 to 50 mg/kg.  

 

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SKU: 10007853 - 1 mg Category:

Description

A dual agonist of PPARα and PPARγ (EC50s = 0.32 and 0.11 μM, respectively); selective for PPARα/γ over other nuclear receptors, including PPARδ, RXRα, RARs, ERα/β, AR, and PR; reduces the size of lipid droplets in oleic acid-treated HepaRG human hepatocytes at 50 μM; reduces plasma levels of glucose, triglycerides, free fatty acids, and insulin by 54, 33, 62, and 48%, respectively, in db/db mice at 10 mg/kg per day; reduces plasma levels of glucose, triglycerides, and cholesterol in diet-induced obese mice at 10 mg/kg per day; inhibits LPS-induced increases in NO production and IL-6, TNF-α, and iNOS protein levels in J774 murine macrophages; inhibits carrageenan-induced paw edema in mice at 12.5-50 mg/kg

Formal name: N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-glycine

Synonyms:  BMS-298585

Molecular weight: 516.5

CAS: 331741-94-7

Purity: ≥98%

Formulation: A crystalline powder

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation|Innate Immunity

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