Description
An S1P1 receptor agonist (IC50 = 0.6 nM); selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays; reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved at 10, 0.5, and 0.5 mg/kg, respectively; increases graft survival in a rat skin allograft model at 5 mg/kg per day in combination with CsA
Formal name: 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-3-azetidinecarboxylic acid
Synonyms:
Molecular weight: 391.5
CAS: 635701-59-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Immunosuppressants||Research Area|Lipid Biochemistry|Sphingolipids
