Acidic PEAase is an enzyme that promotes the hydrolysis of palmitoylethanolamide. A selective inhibitor of acidic PEAase (IC50 = 4.5 µM) that fails to inhibit FAAH even at a concentration of 100 µM

N-Cyclohexanecarbonylpentadecylamine – 50 mg

Brand:
Cayman
CAS:
702638-84-4
Storage:
-20
UN-No:
Non-Hazardous - /

Numerous analogs of fatty acyl ethanolamides potentiate the intrinsic biological activity of endocannabinoids.{10254} This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. {10647} However, Ueda has recently cloned another amidase, the acidic palmitoyl ethanolamidase (PEAase) that promotes the hydrolysis of palmitoylethanolamide.{9989} N-Cyclohexanecarbonylpentadecylamine is a selective inhibitor of acidic PEAase, inhibiting the enzyme with an IC50 of 4.5 µM, while failing to inhibit FAAH even at 100 µM.{13342}  

 

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SKU: 10007739 - 50 mg Category:

Description

Acidic PEAase is an enzyme that promotes the hydrolysis of palmitoylethanolamide. A selective inhibitor of acidic PEAase (IC50 = 4.5 µM) that fails to inhibit FAAH even at a concentration of 100 µM

Formal name: N-pentadecyl-cyclohexanecarboxamide

Synonyms: 

Molecular weight: 337.6

CAS: 702638-84-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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