Description
HMB-val-ser-leu-VE is a tripeptide bearing a C-terminal vinyl ester which acts as a potent, selective inhibitor of the trypsin-like activity of the 20S proteasome. It inhibits the tryptic-like, chymotryptic-like, and post acidic activities of the purified 20S proteasome with IC50 values of 0.33 µM, >10 µM, and >10 µM, respectively.{13343} HMB-val-ser-leu-VE is cell permeable and stable (t½ ~6 hours) in in vitro assays.
Formal name: N-(3-hydroxy-2-methylbenzoyl)-L-valyl-N-[(1S,2E)-4-ethoxy-1-(2-methylpropyl)-4-oxo-2-butenyl]-L-serinamide
Synonyms:
Molecular weight: 505.6
CAS: 862891-04-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System
