A “hybrid” analog which incorporates components of both the AEA-like and dopaminergic neurotransmitter pathways; is nearly inactive as a TRPV1 ligand and fails to elicit hyperalgesic or nocifensive responses in vivo; exhibits an “entourage” effect at concentrations of 0.1-10 µM by potentiating the TRPV1-mediated effects of NADA and AEA

N-Palmitoyl Dopamine – 5 mg

Brand:
Cayman
CAS:
136181-87-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Several different fatty acyl dopamine analogs, such as N-arachidonoyl dopamine (NADA), N-oleoyl dopamine (ODA) and N-palmitoyl dopamine (PALDA), have been isolated and characterized from bovine brain.{9589,11117} Structurally, PALDA is the amide of palmitic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. Unlike NADA and ODA, PALDA is nearly inactive as a vanilloid receptor 1 (VR1) ligand and fails to elicit hyperalgesic or nocifensive responses in vivo.{11117} However, PALDA exhibits an “entourage” effect at concentrations of 0.1-10 µM by potentiating the VR1-mediated effects of NADA and anandamide.{13227}  

 

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SKU: 10007697 - 5 mg Category:

Description

A “hybrid” analog which incorporates components of both the AEA-like and dopaminergic neurotransmitter pathways; is nearly inactive as a TRPV1 ligand and fails to elicit hyperalgesic or nocifensive responses in vivo; exhibits an “entourage” effect at concentrations of 0.1-10 µM by potentiating the TRPV1-mediated effects of NADA and AEA

Formal name: N-[2-(3,4-dihydroxyphenyl)ethyl]-hexadecanamide

Synonyms:  PALDA

Molecular weight: 391.6

CAS: 136181-87-8

Purity: >98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Amides||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience

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