A potent

Acetyl Podocarpic Acid Anhydride – 1 mg

Brand:
Cayman
CAS:
344327-48-6
Storage:
-20
UN-No:
Non-Hazardous - /

The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols.{8532} Acetyl podocarpic acid anhydride (APD) is potent, semi-synthetic LXR agonist derived from extracts of the mayapple. APD acting through LXR in concert with the retinoid X receptor (RXR), its heterodimerization partner, induces the expression of the ABCA1 reverse cholesterol transporter.{9803} This acts to increase the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol (ED50 value of 1 nM).{13311} In transient transactivation assays, APD was found to be approximately 1,000 times more potent and have 8-10-fold greater maximal stimulation of LXR than 22(R)-hydroxy cholesterol.{13311,13312} APD can be used as a positive control for the testing of LXR agonists, which have potential as therapeutic agents for the treatment of atherosclerosis.  

 

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SKU: 10007686 - 1 mg Category:

Description

A potent, semi-synthetic LXR agonist derived from extracts of the mayapple; induces the expression of the ABCA1 reverse cholesterol transporter to increase the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol (ED50 = 1 nM)

Formal name: 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-1-phenanthrenecarboxylic acid, anhydride

Synonyms:  APD

Molecular weight: 614.8

CAS: 344327-48-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs

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