A potent

(S)-H-1152 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
451462-58-1
Storage:
-20
UN-No:
Non-Hazardous - /

Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM).{17660}{17661} It is a more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM).{17661} H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).{17661} It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly,{17662} vasoconstriction,{17663} as well as spontaneously tonic smooth muscle{17664} and neurite extension.{17665}  

 

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SKU: 10007653 - 10 mg Category:

Description

A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK

Formal name: 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-isoquinoline, dihydrochloride

Synonyms: 

Molecular weight: 392.3

CAS: 451462-58-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|ROCK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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