A selective inhibitor of MAGL (IC50 = 28 µM for the rat brain enzyme); does not inhibit FAAH at concentrations up to 100 µM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2; inhibits glucose-stimulated and depolarization-induced insulin secretion in INS-1 cells

URB602 – 5 mg

Brand:
Cayman
CAS:
565460-15-3
Storage:
-20
UN-No:
Non-Hazardous - /

URB602 is a selective inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 28 µM for the rat brain enzyme.{13217} It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 µM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2.{13217,11304} Inhibition of MAGL inhibits 2-arachidonoyl glycerol (Item No. 62160) hydrolysis, which is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.{13217} URB602 (50 µM) also inhibits glucose-stimulated and depolarization-induced insulin secretion in INS-1 cells.{38096}  

 

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SKU: 10007457 - 5 mg Category:

Description

A selective inhibitor of MAGL (IC50 = 28 µM for the rat brain enzyme); does not inhibit FAAH at concentrations up to 100 µM or other lipid metabolizing enzymes such as diacylglycerol lipase or COX-2; inhibits glucose-stimulated and depolarization-induced insulin secretion in INS-1 cells,

Formal name: N-[1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester

Synonyms: 

Molecular weight: 295.4

CAS: 565460-15-3

Purity: ≥98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Neuroscience|Cannabinoid Research||Research Area|Neuroscience|Pain Research

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