A potent tubulin polymerization inhibitor that reduces tumor growth in P-388 (leukemia)

Combrestatin A4 3′-O-Phosphate (sodium salt) – 25 mg

Brand:
Cayman
CAS:
168555-66-6
Storage:
-20
UN-No:
Non-Hazardous - /

Combretastatin A4 (CA4) is a potent inhibitor of tubulin polymerization that displays strong inhibitory activity on tumor cell growth. Combretastatin-A-4-3’-O-Phosphate (CA4P) is a CA4 prodrug that inhibits tumor growth in several cell lines including P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) with ED50 values of 0.0029, 0.00025, 0.23, 0.00035, and 0.00072 µg/ml, respectively.{13212} CA4P specifically targets the tumor vasculature. In a rat model of carcinosarcoma, CA4P delivered intraperitoneally at a dose of 100 mg/kg effectively disrupts tumor blood flow within six hours after administration without significantly affecting normal tissues.{15817}  

 

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SKU: 10007415 - 25 mg Category:

Description

A potent tubulin polymerization inhibitor that reduces tumor growth in P-388 (leukemia), SK-N-SH (neuroblast), BXPC-3 (pancreas), NCI-H460 (lung), and DU-145 (prostate) cell lines with ED50 values of 0.0029, 0.00025, 0.23, 0.00035, and 0.00072 µg/ml, respectively; disrupts tumor blood flow in a rat model of carcinosarcoma at a dose of 100 mg/kg without affecting normal tissues

Formal name: 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol, dihydrogen phosphate, disodium salt

Synonyms:  CA4P|Combrestatin A4|CRC 87-09

Molecular weight: 440.3

CAS: 168555-66-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Angiogenesis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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