A natural proteasome inhibitor that irreversibly inhibits all three protease activities within the proteasome (IC50s = 3.5

Salinosporamide A – 100 µg

Brand:
Cayman
CAS:
437742-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

Salinosporamide A is a natural proteasome inhibitor.{31311} It is a β-lactone-γ-lactam that irreversibly inhibits all three protease activities within the proteasome (IC50s = 3.5, 28, and 430 nM for β5 (chymotrypsin), β2 (macropain), and β1 (C5) subunits, respectively), both in vitro and in vivo.{15120,31310} Salinosporamide A has potential applications in cancer therapy, particularly in combination with other chemotherapeutics.{31311,15120}  

 

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SKU: 10007311 - 100 µg Category:

Description

A natural proteasome inhibitor that irreversibly inhibits all three protease activities within the proteasome (IC50s = 3.5, 28, and 430 nM for β5 (chymotrypsin), β2 (macropain), and β1 (C5) subunits, respectively), both in vitro and in vivo

Formal name: (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione

Synonyms:  Marizomib|ML-858|NPI-0052

Molecular weight: 313.8

CAS: 437742-34-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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