One of serveral novel taurine-conjugated fatty acids that act as a FAAH substrate and may activate TRPV1 and TRPV4

N-Docosanoyl Taurine – 1 mg

Brand:
Cayman
CAS:
783284-48-0
Storage:
-20
UN-No:
Non-Hazardous - /

Several different arachidonoyl amino acid conjugates, including N-arachidonoyl dopamine and N-arachidonoyl-L-serine, have been isolated and characterized from bovine brain.{9589} N-Docosanoyl taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of brain and spinal cord from wild-type and fatty acid amide hydrolase (FAAH) knockout mice.{13153} The levels of N-docosanoyl taurine were elevated ~12 fold in FAAH-/- mice compared to wild-type mice, indicating that FAAH utilizes N-docosanoyl taurine as a substrate. However, in vitro experiments with purified FAAH indicate that related N-fatty acyl taurines and ethanolamines of similar chain length are hydrolyzed 2,000-50,000 times more slowly by FAAH compared to oleoyl ethanolamide.{13153} N-acyl taurines bearing polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) family of calcium channels, including TRPV1 and TRPV4.{16245}  

 

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SKU: 10007288 - 1 mg Category:

Description

One of serveral novel taurine-conjugated fatty acids that act as a FAAH substrate and may activate TRPV1 and TRPV4

Formal name: 2-[(1-oxodocosyl)amino]-ethanesulfonic acid

Synonyms: 

Molecular weight: 447.7

CAS: 783284-48-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Docosanoids||Product Type|Biochemicals|Lipids|Fatty Amides||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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