A potent

nor-NOHA (acetate) – 1 mg

Brand:
Cayman
CAS:
1140844-63-8
Storage:
-20
UN-No:
Non-Hazardous - /

L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. nor-NOHA (acetate) is a potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA.{13098} It is about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM.{13096} nor-NOHA (acetate) is not a substrate for any of the 3 NOS isoforms and does not inhibit nNOS or iNOS.{13095, 13100}  

 

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SKU: 10006861 - 1 mg Category:

Description

A potent, reversible inhibitor of rat liver arginase with a Ki value of 0.5 µM, which is 20-fold lower than the Ki of 10 µM observed for NOHA; about 40-fold more potent than NOHA as an inhibitor of arginase from mouse macrophages, exhibiting an IC50 of 10-12 µM; not a substrate for any of the 3 NOS isoforms; does not inhibit nNOS or iNOS

Formal name: 2S-amino-4-[[(hydroxyamino)iminomethyl]amino]-butanoic acid, diacetate

Synonyms:  Nω-hydroxy-nor-Arginine

Molecular weight: 296.3

CAS: 1140844-63-8

Purity: ≥97%

Formulation: A lyophilized powder

Application|Enzyme Activity||Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area

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