The PLAs are an extensive family of lipid hydrolases that function in cell signaling

(S)-Bromoenol lactone – 10 mg

Brand:
Cayman
CAS:
478288-94-7
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.{12978} (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.  

 

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SKU: 10006801 - 10 mg Category:

Description

The PLAs are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The iPLA2 are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-BEL is an irreversible, chiral, mechanism-based inhibitor of iPLA2β that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.{12978} (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.

Formal name: 6E-(bromoethylene)tetrahydro-3S-(1-naphthalenyl)-2H-pyran-2-one

Synonyms:  (S)-BEL

Molecular weight: 317.2

CAS: 478288-94-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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