The PLAs are an extensive family of lipid hydrolases that function in cell signaling

(R)-Bromoenol lactone – 1 mg

Brand:
Cayman
CAS:
478288-90-3
Storage:
-20
UN-No:
De Minimis - 1231 / 3

The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.{12978} (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.  

 

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SKU: 10006800 - 1 mg Category:

Description

The PLAs are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The iPLA2 are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-BEL is an irreversible, chiral, mechanism-based inhibitor of iPLA2γ. Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.{12978} (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.

Formal name: 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl)-2H-pyran-2-one

Synonyms:  (R)-BEL

Molecular weight: 317.2

CAS: 478288-90-3

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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