A MAPK pathway inhibitor and AMPK activator; prevents the activation of MAPKK1 by Raf or MEK kinase (IC50 = 2-7 µM); activator of AMPK (EC50 = 35 µM); increases the ratios of ADP:ATP and AMP:ATP

PD 98059 – 1 mg

Brand:
Cayman
CAS:
167869-21-8
Storage:
-20
UN-No:
Non-Hazardous - /

PD 98059 is a noncompetitive inhibitor of the MAPK pathway.{12847,10421} It prevents the activation of MEK by Raf or MEK kinase (a MAPKKK) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAPKK1.{13126} It inhibits Raf activation of MAPKK2 with an IC50 value of 50 µM.{13126} PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).  

 

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SKU: 10006726 - 1 mg Category:

Description

A MAPK pathway inhibitor and AMPK activator; prevents the activation of MAPKK1 by Raf or MEK kinase (IC50 = 2-7 µM); activator of AMPK (EC50 = 35 µM); increases the ratios of ADP:ATP and AMP:ATP

Formal name: 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  NSC 679828

Molecular weight: 267.3

CAS: 167869-21-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Endocrinology & Metabolism|Nutrient Sensing

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