Palmitic Acid – 25 g

Brand:
Cayman
CAS:
57-10-3
Storage:
-20
UN-No:
Non-Hazardous - /

Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.{45765,1935} Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins, promotes protein-vesicle interactions, and regulates various G protein-coupled receptor functions.{45765} Palmitic acid (200 µM) increases NF-ĸB p65 levels, matrix metalloproteinase-9 (MMP-9) activity, and production of reactive oxygen species (ROS) in AsPC-1 pancreatic cancer cells, as well as increases migration of AsPC-1 cells.{45766} It increases COX-2 levels in RAW 264.7 cells and increases LPS-induced IL-1β levels and caspase-1 activity in isolated mouse peritoneal macrophages.{10646,45767} Dietary administration of palmitic acid (2.2% w/w for 12 weeks) increases mouse hippocampal β-secretase 1 (BACE1) activity and amyloid β (1-42) (Aβ42; Item No. 20574) levels.{45768} It also induces systolic contractile dysfunction in isolated mouse hearts.{45769} Red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes.{45771,45772}  

 

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SKU: 10006627 - 25 g Category:

Description

,A long-chain saturated fatty acid; comprises ~25 and 65% of the human total plasma lipids and saturated fatty acids, respectively; acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins, promotes protein-vesicle interactions, and regulates various G protein-coupled receptor functions; increases NF-ĸB p65 levels, MMP-9 activity, and production of ROS in in AsPC-1 pancreatic cancer cells, as well as increases migration of AsPC-1 cells at 200 µM; increases COX-2 levels in RAW 264.7 cells and increases LPS-induced IL-1β levels and caspase-1 activity in isolated mouse peritoneal macrophages; increases mouse hippocampal BACE1 activity and Aβ42 levels in mice at 2.2% w/w for 12 weeks in the diet; induces systolic contractile dysfunction in isolated mouse hearts; red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes

Formal name: hexadecanoic acid

Synonyms:  C16:0

Molecular weight: 256.4

CAS: 57-10-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Tumor Microenvironment||Research Area|Cardiovascular System|Blood|Erythrocytes & Hemoglobin||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Metabolic Syndrome||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Protein Lipidation||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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