A selective agonist of FXR (EC50 = 15 nM); displays no activity at other nuclear receptors

GW 4064 – 10 mg

Brand:
Cayman
CAS:
278779-30-9
Storage:
-20
UN-No:
Non-Hazardous - /

Farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity.{15284} GW 4064 is a selective agonist of FXR (EC50 = 15 nM).{12563} It displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM.{12563} GW 4064 is used to elucidate the role of FXR in dyslipidemia, diabetes, obesity, and cancer.{25476,25477,25475,25474,25473}  

 

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SKU: 10006611 - 10 mg Category:

Description

A selective agonist of FXR (EC50 = 15 nM); displays no activity at other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM

Formal name: 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-benzoic acid

Synonyms: 

Molecular weight: 542.8

CAS: 278779-30-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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