An AT1 receptor antagonist (Ki = 5-20 nM); attenuates vein graft atherosclerosis in rabbits and reduces arterial blood pressure in rats; controls hypertension while protecting renal function

Losartan (potassium salt) – 500 mg

Brand:
Cayman
CAS:
124750-99-8
Storage:
-20
UN-No:
Non-Hazardous - /

Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is an AT1 receptor antagonist with a Ki value of 5-20 nM.{12997} It has an attenuating effect on vein graft atherosclerosis in rabbits and effectively reduces arterial blood pressure in rats.{12998,13089} In humans, losartan controls hypertension while protecting renal function.{12996}  

 

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SKU: 10006594 - 500 mg Category:

Description

An AT1 receptor antagonist (Ki = 5-20 nM); attenuates vein graft atherosclerosis in rabbits and reduces arterial blood pressure in rats; controls hypertension while protecting renal function, in humans

Formal name: 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt

Synonyms:  DuP-753|MK 954

Molecular weight: 461

CAS: 124750-99-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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