PUFAs are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525

γ-Linolenic Acid methyl ester – 250 mg

Brand:
Cayman
CAS:
16326-32-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525,8460} γ-Linolenic Acid methyl ester (Methyl GLA) is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak leukotriene B4 (LTB4) receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.{2361} GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}  

 

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SKU: 10006579 - 250 mg Category:

Description

PUFAs are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet.{5525,8460} Methyl GLA is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM.{2361} GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}

Formal name: 6Z,9Z,12Z-octadecatrienoic acid, methyl ester

Synonyms:  Methyl GLA|Methyl γ-Linolenate

Molecular weight: 292.5

CAS: 16326-32-2

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Lipid Biochemistry|Fatty Acids

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