A synthetic steroid used occasionally to treat endometriosis; binds to androgen

Gestrinone – 1 g

Brand:
Cayman
CAS:
16320-04-0
Storage:
-20
UN-No:
Non-Hazardous - /

Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.{12994} It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.{12994} It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.{13002} Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.{12992} These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.{12992}  

 

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SKU: 10006488 - 1 g Category:

Description

A synthetic steroid used occasionally to treat endometriosis; binds to androgen, and progesterone receptors with EC50 values of approximately 20 and 30 nM, respectively

Formal name: 13-ethyl-17α-hydroxy-18,19-dinorpregna-4,9,11-trien-20-yn-3-one

Synonyms: 

Molecular weight: 308.4

CAS: 16320-04-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology

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