An inhibitor of human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM

CAY10485 – 10 mg

Brand:
Cayman
CAS:
615264-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.{10960,11758} CAY10485 inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively.{12441} It also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 µM.{12441}  

 

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SKU: 10006482 - 10 mg Category:

Description

An inhibitor of human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 µM, respectively; inhibits cooper-mediated oxidation of LDL by 91% at concentration of 2 µM

Formal name: N-[3-(3,4-dihydroxyphenyl)-1-oxopropyl]-L-aspartic acid, bis(phenylmethyl) ester

Synonyms:  3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide

Molecular weight: 477.5

CAS: 615264-62-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation

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