Description
Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is a mammalian AT1 receptor antagonist with a Ki of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} NO causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442}
Formal name: [2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl] methyl ester
Synonyms:
Molecular weight: 602
CAS: 791122-48-0
Purity: ≥97%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|NO Donors||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Endocrinology & Metabolism|Hormones & Receptors
