Single stereoisomer of FTY720-phosphate formed in vivo; exhibits Ki values of 2.1

FTY720 (S)-Phosphate – 5 mg

Brand:
Cayman
CAS:
402616-26-6
Storage:
-20
UN-No:
Non-Hazardous - /

FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.{11265} FTY720 is phosphorylated by sphingosine kinases in vivo, and then acts as a potent agonist at four of the five sphingosine-1-phosphate (S1P) receptors.{11284} FTY720 (S)-phosphate is the single stereoisomer formed by phosphorylation of FTY720 in vivo, as determined in rats and humans.{17113} It exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, whereas the R enantiomer binds with 5 to 130-fold lower affinity.{17114} FTY720 (S)-phosphate causes internalization of S1P1 on lymphocytes, abrogating S1P-dependent egress of lymphocytes from lymphoid organs.{13737} It also enhances endothelial barrier function,{13737} stimulates the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1{11283} and inhibits cytosolic phospholipase A2 activity.{14604}  

 

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SKU: 10006408 - 5 mg Category:

Description

Single stereoisomer of FTY720-phosphate formed in vivo; exhibits Ki values of 2.1, 5.9, 23, and 2.2 nM for S1P1,3,4,5, respectively, which are 5-130-fold lower than those observed for the FTY720 (R)-phosphate

Formal name: (2S)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol

Synonyms:  (S)-FTY 720P

Molecular weight: 387.5

CAS: 402616-26-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases||Research Area|Lipid Biochemistry|Lipid Transport||Research Area|Lipid Biochemistry|Sphingolipids

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