A ceramidase inhibitor; induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner; increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells; reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models at 75 mg/kg

D-NMAPPD – 1 mg

Brand:
Cayman
CAS:
35922-06-6
Storage:
-20
UN-No:
Non-Hazardous - /

D-NMAPPD is an inhibitor of ceramidase.{12571} It induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner but has no effect on viability of rat hepatocytes, Kupffer cells, or sinusoidal endothelial cells when used at a concentration of 100 mM. D-NMAPPD increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells, effects that can be prevented by the caspase-3 inhibitor Ac-DEVD-CHO (Item No. 10017). In vivo, D-NMAPPD (75 mg/kg) reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models.  

 

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SKU: 10006305 - 1 mg Category:

Description

A ceramidase inhibitor; induces cell death in SW403 colon adenocarcinoma cells in a time- and concentration-dependent manner; increases intracellular ceramide accumulation and cytochrome C release and induces apoptosis in SW403 cells; reduces tumor growth and the number of hepatic metastases in SW403 and LoVo colon cancer mouse xenograft models at 75 mg/kg

Formal name: N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-tetradecanamide

Synonyms:  (1R,2R)-B13|CAY10466

Molecular weight: 422.6

CAS: 35922-06-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Lipid Biochemistry|Sphingolipids

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