An NSAID that inhibits COX-2 selectively over COX-1 (IC50s = 0.005 and 3.3 μM

Cimicoxib – 1 mg

Brand:
Cayman
CAS:
265114-23-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cimicoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2 selectively over COX-1 (IC50s = 0.005 and 3.3 μM, respectively). {47333,11434} It inhibits paw swelling by 93% in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg.{11434} Cimicoxib (3 mg/kg, p.o.) inhibits carrageenan-induced decreases in paw withdrawal latency in the hot plate test in a rat model of hyperalgesia. Formulations containing cimicoxib have been used in the treatment of pain and inflammation associated with osteoarthritis or surgery in dogs.  

 

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SKU: 10006295 - 1 mg Category:

Description

An NSAID that inhibits COX-2 selectively over COX-1 (IC50s = 0.005 and 3.3 μM, respectively); inhibits paw swelling by 93% in a rat model of adjuvant-induced arthritis at 1 mg/kg; inhibits carrageenan-induced decreases in paw withdrawal latency in the hot plate test in a rat model of hyperalgesia at 3 mg/kg, p.o.

Formal name: 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]-benzenesulfonamide

Synonyms:  UR-8880

Molecular weight: 381.8

CAS: 265114-23-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research

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